Endocrine Abstracts

Introduction: We evaluated glycemia and the iron status in patients with NT-SCD and 6 patients with TD- SCD by measuring serum ferritin level (SF), liver iron content (LIC), alanine transferase (ALT) and fasting blood glucose (FBG) over 5 years of follow up.Results: At the initial assessment, 16 adults with (age: 33±14 years), and six of TD-SCD (n=6, age =25±10 years) were studied. 6/16 of NT-SCD had SF > 500 μg/l, and 5/16 ha...

Introduction: In patients with β thalassemia major (TM) The interplay between liver siderosis and hepatitis C virus (HCV) infection may facilitates the progression to insulin resistance (IR) and diabetes mellitus (DM).Objectives: Many TM patients are infected with either HCV. Therefore, we aimed to explore if there is any association between DM and HCV-RNA positivity with different genotypes.Patients and methods: 148 TM patien...

GHD in adults (AGHD) is a clinical syndrome associated with lack of positive well-being, depressed mood, feelings of social isolation, decreased energy, alterations in body composition with reduced bone and muscle mass, diminished exercise performance, and cardiac capacity. These manifestations are also common in adults with beta-thalassemia major (BTM). Performing provocative testing in all patients is cumbersome and expensive. Many studies suggested that IGF1 may be used for...

To investigate the best criteria and time to diagnose dysglycemia in β-TM patients, the ICETA performed a retrospective study on glycemic abnormalities (GD) in 397 with β-TM patients (aged 5–40 years; 56.3% males) followed between 1988 to 2021 in a single centre (by VDS) (40 years).Methods: Fasting blood glucose (FPG) and standard oral glucose tolerance test (OGTT) results were collected over 40 years of follow up and results were categori...